Bone Marrow Concentrate Injection for Osteonecrosis/AVN

Procedure: During a BMC injection procedure, a small amount of bone marrow is typically extracted from the patient's hip bone. The bone marrow contains various cell types, including mesenchymal stem cells (MSCs) and growth factors that have regenerative potential. The extracted bone marrow is processed to concentrate the desired cell population, primarily MSCs, which have the ability to differentiate into different cell types, including bone-forming cells (osteoblasts). The concentrated BMC is then injected directly into the affected area of the necrotic bone.

Mechanism of Action: The MSCs present in the BMC have the potential to differentiate into osteoblasts, which are responsible for bone formation and regeneration. When injected into the necrotic area, these MSCs may help stimulate new bone growth, potentially improving blood supply and restoring bone structure. Additionally, MSCs can release growth factors and cytokines that promote angiogenesis (formation of new blood vessels) and modulate the local immune response, supporting tissue healing.

Potential Benefits: BMC injection for osteonecrosis/AVN offers several potential benefits:
Enhanced Bone Regeneration: The presence of MSCs in the injected BMC may promote the regeneration of new bone tissue in the necrotic area, potentially improving bone structure and function.
Angiogenesis Promotion: MSCs and growth factors in BMC have the potential to stimulate the formation of new blood vessels, which can help improve blood supply to the necrotic bone.
Anti-inflammatory Effects: MSCs possess anti-inflammatory properties, which may help reduce inflammation in the affected area and create a favorable environment for healing.
Minimally Invasive Procedure: BMC injection is a minimally invasive procedure that can be performed on an outpatient basis, potentially reducing associated risks and recovery time compared to more invasive surgical options.